Publication list 1994-

Publication List 1994-present

X. C. Su, K. Ozawa, R. Qi, S. G. Vasudevan, S. P. Lim, G. Otting

NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile virus NS2B-NS3 protease.
PLoS Negl. Trop. Dis. in press (2009)

C. Bodenreider, D. Beer, T. H. Keller, S. Sonntag, D. Wen, L. Yap, Y. H. Yau, S. Geifman Shochat, D. Huang, T. Zhou, A. Caflisch, X. C. Su, K. Ozawa, G. Otting, S. G. Vasudevan, J. Lescar, S. P. Lim
A fluorescence quenching assay to discriminate between specific and non-specific inhibitors of dengue virus protease.
Anal. Biochem. in press (2009)

X. C. Su, H. Liang, K. V. Loscha, G. Otting
[Ln(DPA)3]3- is a convenient paramagnetic shift reagent for protein NMR studies
J. Am. Chem. Soc. 131, 10352-10353 (2009)       (mail for reprint) and (supplementary material)

Y. Xun, P. Tremouilhac, C. Carraher, C. Gelhaus, K. Ozawa, G. Otting, N. E. Dixon, M. Leippe, J. Grötzinger, A. J. Dingley, A. V. Kralicek
Cell-free synthesis and combinatorial selective 15N labeling of the cytotoxic protein amoebapore A from Entamoeba histolytica.
Prot. Expr. Purif. in press (2009)

D. Ekonomiuk, X. C. Su, K. Ozawa, C. Bodenreider, S. P. Lim, G. Otting, D. Huang, A. Caflisch
Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics
J. Med. Chem. 52, 4860-4868 (2009)            (mail for reprint) and (supplementary material)

X. C. Su, K. Ozawa, H. Yagi, S. P. Lim, D. Wen, D. Ekonomiuk, D. Huang, T. H. Keller, S. Sonntag, A. Caflisch, S. G. Vasudevan, G. Otting
NMR study of complexes between low-molecular weight inhibitors and the West Nile virus NS2B-NS3 protease
FEBS J. 276, 4244-4255 (2009)                     (mail for reprint) and (supplementary material)

X. C. Su, G. Otting
Paramagnetic labelling of proteins and oligonucleotides for NMR
J. Biomol. NMR in press (2009)

X. Jia, K. Ozawa, K. Loscha, G. Otting
Glutarate and N-acetyl-L-glutamate buffers for cell-free synthesis of selectively 15N-labelled proteins
J. Biomol. NMR 44, 59-67 (2009)                  (mail for reprint) and (supplementary material)

K. V. Loscha, K. Jaudzems, C. Ioannou, X. C. Su, F. R. Hill, G. Otting, N. E. Dixon, E. Liepinsh
Solution structure of the N-terminal domain of the Bacillus subtilis helicase-loading protein DnaI and interaction with the helicase
Nucl. Acids Res. 37, 2395-2404 (2009)        (link to Open Access article) and (supplementary material in PDF format)

D. Ekonomiuk, X. C. Su, K. Ozawa, C. Bodenreider, S. P. Lim, Z. Yin, T. H. Keller, D. Beer, V. Patel, G. Otting, A. Caflisch, D. Huang
Discovery of a non-peptidic inhibitor of West Nile virus NS3 protease by high-throughput docking
PLoS Negl. Trop. Dis. 3, e356 (2009)           (link to Open Access article)

Z. Wu, X. Jia, L. de la Cruz, X. C. Su, B. Marzolf, P. Troisch, D. Zak, A. Hamilton, B. Whittle, D. Yu, D. Sheahan, E. Bertram, A. Aderem, G. Otting, C. C. Goodnow, G. Hoyne
Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL
Immunity 29, 863-875 (2008)                        (mail for reprint) and (supplementary material)

S. Dabb, B. A. Messerle, G. Otting, J. Wagler, A. Willis
Ruthenium complexes of substituted hydrazine - novel solution and solid state binding modes
Chem.-Eur. J. 14, 10058-10065 (2008)          (mail for reprint)

K. Ozawa, S. Jergic, A. Y. Park, N. E. Dixon, G. Otting
The proofreading exonuclease subunit epsilon of Escherichia coli DNA polymerase III is tethered to the polymerase subunit alpha via a flexible linker
Nucl. Acids Res. 36, 5074-5084 (2008)         (mail for reprint) and (supplementary material)

G. Otting
Prospects for lanthanides in structural biology by NMR
J. Biomol. NMR 42, 1-9 (2008)                       (mail for reprint)

X. C. Su, B. Man, S. Beeren, H. Liang, S. Simonsen, C. Schmitz, T. Huber, B. A. Messerle, G. Otting
A dipicolinic acid tag for rigid lanthanide tagging of proteins and paramagnetic NMR spectroscopy
J. Am. Chem. Soc. 130, 10486-10487 (2008)           (mail for reprint) and (supplementary material)

C. Schmitz, M. J. Stanton-Cook, X. C. Su, G. Otting, T. Huber
Numbat: an interactive software tool for fitting DeltaChi-tensors to molecular coordinates using pseudocontact shifts
J. Biomol. NMR 41, 179-189 (2008)             (mail for reprint) and (supplementary material)

X. C. Su, K. McAndrew, T. Huber, G. Otting
Lanthanide-binding peptides for NMR measurements of residual dipolar couplings and paramagnetic effects from multiple angles
J. Am. Chem. Soc. 130, 1681-1687 (2008) (mail for reprint) and (supplementary material)

M. John, C. Schmitz, A. Y. Park, N. E. Dixon, T. Huber, G. Otting
Sequence- and stereospecific assignment of methyl groups using paramagnetic lanthanides
J. Am. Chem. Soc. 129, 13749-13757 (2007)           (mail for reprint) and (supplementary material)

M. John, G. Otting
Strategies for the measurement of pseudocontact shifts in protein NMR spectroscopy
ChemPhysChem 8, 2309-2313 (2007)          (mail for reprint)

S. J. Watt, M. M. Sheil, J. L. Beck, P. Prosselkov, G. Otting, N. E. Dixon
Effect of protein stabilization on charge state distribution in positive and negative ion electrospray ionization mass spectra
J. Am. Soc. Mass Spectr. 18, 1605-1611 (2007)    (mail for reprint)

D. Padmakshan, S. A. Bennett, G. Otting, C. J. Easton
Stereocontrolled synthesis of (S)-gamma-fluoroleucine
Synlett 7, 1083-1084 (2007)                           (mail for reprint)

S. Jergic, K. Ozawa, N. K. Williams, X. C. Su, D. D. Scott, S. M. Hamdan, J. A. Crowther, G. Otting, N. E. Dixon
The unstructured C-terminus of the tau subunit of Escherichia coli DNA polymerase III holoenzyme is the site of interaction with the alpha subunit
Nucl. Acids Res. 35, 2813-2824 (2007)        (reprint) and (supplementary material)

X. C. Su, S. Jergic, M. A. Keniry, N. E. Dixon, G. Otting
Solution structure of domains IVa and V of the tau subunit of Escherichia coli DNA polymerase III and interaction with the alpha subunit
Nucl. Acids Res. 35, 2825-2832 (2007)        (reprint) and (supplementary material)

P. S. C. Wu, K. Ozawa, S. P. Lim, S. Vasudevan, N. E. Dixon, G. Otting
Cell-free transcription/translation from PCR amplified DNA for high-throughput NMR studies
Angew. Chemie Int. Ed. 46, 3356-3358 (2007)     (mail for PDF reprint) and (supplementary material) or (German version)

X. C. Su, S. Jergic, K. Ozawa, N. D. Burns, N. E. Dixon, G. Otting
Measurement of dissociation constants of high molecular weight protein-protein complexes by transferred 15N-relaxation
J. Biomol. NMR 38, 65-72 (2007)                    (mail for PDF reprint)

M. John, A. Y. Park, N. E. Dixon, G. Otting
NMR detection of protein 15N-spins near paramagnetic lanthanide ions
J. Am. Chem. Soc. 129, 462-463 (2007)         (mail for PDF reprint) and (supplementary material)

G. Pintacuda, M. John, X. C. Su, G. Otting
NMR structure determination of protein-ligand complexes by lanthanide labeling
Acc. Chem. Res. 40, 206-212 (2007)              (mail for PDF reprint)

M. Apponyi, K. Ozawa, N. E. Dixon, G. Otting
Cell-free protein synthesis for analysis by NMR spectroscopy
Methods in Molecular Biology 426, Structural proteomics: high-throughput methods
B. Kobe, M. Guss, T. Huber Eds., Humana Press, Totowa, USA pp. 257-268 (2008)       (download article)

M. John, M. J. Headlam, N. E. Dixon, G. Otting
Assignment of paramagnetic 15N-HSQC spectra by heteronuclear exchange spectroscopy
J. Biomol. NMR 37, 43-51 (2007)                    (mail for PDF reprint)

G. Pintacuda, T. Huber, M. A. Keniry, A. Y. Park, N. E. Dixon, G. Otting
Fast assignments of 15N-HSQC spectra of proteins by paramagnetic labeling.
In Handbook of Modern Magnetic Resonance, Vol 2, Webb, G. A., Ed., Springer Netherlands, pp. 1245-1250 (2006)

X. C. Su, P. M. Schaeffer, K. V. Loscha, P. H. P. Gan, N. E. Dixon, G. Otting
Monomeric solution structure of the helicase binding domain of Escherichia coli DnaG primase
FEBS J. 273, 4997-5009 (2006)                        (mail for PDF reprint) and (supplementary material)

M. John, G. Pintacuda, A. Y. Park, N. E. Dixon, G. Otting
Structure determination of protein-ligand complexes by transferred paramagnetic shifts
J. Am. Chem. Soc. 128, 12910-12916 (2006)        (mail for PDF reprint) and (supplementary material)

K. Ozawa, P. S. C. Wu, N. E. Dixon, G. Otting
15N-labelled proteins by cell free protein synthesis: strategies for high-throughput NMR studies of proteins and protein-ligand complexes
FEBS J. 273, 4154-4159 (2006)                         (mail for PDF reprint)

X. C. Su, T. Huber, N. E. Dixon, G. Otting
Site-specific labelling of proteins with a rigid lanthanide binding tag
ChemBioChem 7, 1599-1604 (2006)                (mail for PDF reprint) and (supplementary material)

M. A. Keniry, A. Y. Park, E. A. Owen, S. M. Hamdan, G. Pintacuda, G. Otting, N. E. Dixon
Structure of the theta subunit of Escherichia coli DNA polymerase III in complex with the epsilon subunit
J. Bacteriol. 188, 4464-4473 (2006)                  (mail for PDF reprint)

E. Liepinsh, A. Nagy, M. Trexler, L. Patthy, G. Otting
NMR structure note: second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein
J. Biomol. NMR 35, 73-78 (2006)                       (mail for PDF reprint)

G. Pintacuda, A. Y. Park, M. A. Keniry, N. E. Dixon, G. Otting
Lanthanide labeling offers fast NMR approach to 3D structure determinations of protein-protein complexes
J. Am. Chem. Soc. 128, 3696-3702 (2006)       (mail for PDF reprint)

C. Schmitz, M. John, A. Y. Park, N. E. Dixon, G. Otting, G. Pintacuda, T. Huber
Efficient chi-tensor determination and NH assignment of paramagnetic proteins
J. Biomol. NMR 35, 79-87 (2006)                       (mail for PDF reprint) and (supplementary material)

E. Liepinsh, L. Banyai, L. Patthy, G. Otting
NMR structure of the WIF domain of the human Wnt-inhibitory factor-1
J. Mol. Biol. 357, 942-950 (2006)                         (mail for PDF reprint)

M. John, A. Y. Park, G. Pintacuda, N. E. Dixon, G. Otting
Weak alignment of paramagnetic proteins warrants correction for residual CSA effects in measurements of pseudocontact shifts
J. Am. Chem. Soc. 127, 17190-17191 (2005)   (mail for PDF reprint) and (supplementary material)

P. S. C. Wu, K. Ozawa, S. Jergic, X. C. Su, N. E. Dixon, G. Otting
Amino acid type identification in 15N-HSQC spectra by combinatorial selective 15N-labelling
J. Biomol. NMR 34, 13-21 (2006)                        (mail for PDF reprint)

A. F. Hastings, G. Otting, R. H. A. Folmer, I. G. Duggin, G. Wake, M. C. J. Wilce, J. A. Wilce
Interaction of the replication terminator protein of B. subtilis with DNA probed by NMR spectroscopy
Biochem. Biophys. Res. Commun. 335, 361-366 (2005)    (mail for PDF reprint)

K. Ozawa, N. E. Dixon, G. Otting
Cell-free synthesis of 15N-labeled proteins for NMR studies
IUBMB Life 57, 615-622 (2005)                           (mail for PDF reprint)

P. S. C. Wu, G. Otting
SWET for secure water suppression on probes with high quality factor
J. Biomol. NMR 32, 243-250 (2005)                    (mail for PDF reprint) and (supplementary material)

P. S. C. Wu, G. Otting
Rapid pulse-length determination in high-resolution NMR
J. Magn. Reson. 176, 115-119 (2005)                (mail for PDF reprint)

K. Ozawa, S. Jergic, J. A. Crother, P. R. Thompson, G. Wijffels, G. Otting, N. E. Dixon
Cell-free protein synthesis in an autoinduction system for NMR studies of protein-protein interactions
J. Biomol. NMR 32, 235-241 (2005)                    (mail for PDF reprint) and (supplementary material)

K. Ozawa, M. J. Headlam, D. Mouradov, J. L. Beck, K. J. Rogers, R. T. Dean, T. Huber, G. Otting, N. E. Dixon
Translational incorporation of L-3,4-dihydroxyphenylalanine (DOPA) into proteins
FEBS J. 272, 3162-3171 (2005)                            (mail for PDF reprint)

A. J. Oakley, K. V. Loscha, P. M. Schaeffer, E. Liepinsh, G. Pintacuda, M. C. J. Wilce, G. Otting, N. E. Dixon
Crystal and solution structure of the helicase-binding domain of Escherichia coli primase
J. Biol. Chem. 280, 11495-11504 (2005)            (mail for PDF reprint) and (supplementary material)

N. K. Williams, E. Liepinsh, S. J. Watt, P. Prosselkov, J. M. Matthews, P. Attard, J. L. Beck, N. E. Dixon, G. Otting
Stabilization of native protein fold by intein-mediated covalent cyclization
J. Mol. Biol. 346, 1095-1108 (2005)                     (mail for PDF reprint)

A. Robinson, P. S. C. Wu, S. J. Harrop, P. M. Schaeffer, Z. Dosztanyi, M. R. Gillings, A. J. Holmes, K. M. H. Nevalainen, H. W. Stokes, G. Otting, N. E. Dixon, P. M. G. Curmi, B. C. Mabbutt
Integron-associated mobile gene cassettes code for folded proteins: the structure of BaI32a, a new member of the adaptable alpha+beta barrel family
J. Mol. Biol. 346, 1229-1241 (2005)                      (mail for PDF reprint)

M. Moriya, S. Taniguchi, P. Wu, E. Liepinsh, G. Otting, J. Sagara
Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC
Biochemistry 44, 575-583 (2005)                        (mail for PDF reprint)

M. Hoshino, G. Otting
Sensitivity-enhanced double-TROSY experiment for simultaneous measurement of one-bond 15N-1H, 15N-13C and two-bond 1H-13C' couplings
J. Magn. Reson. 171, 270-276 (2004)                  (mail for PDF reprint)

G. Pintacuda, A. Kaikkonen, G. Otting
Modulation of the distance dependence of paramagnetic relaxation enhancements by CSAxDSA cross-correlation
J. Magn. Reson. 171, 233-243 (2004)                  (mail for PDF reprint)

K. Ozawa, M. J. Headlam, P. M. Schaeffer, B. R. Henderson, N. E. Dixon, G. Otting
Optimization of an Escherichia coli system for cell-free synthesis of selectively 15N-labelled proteins for rapid analysis by NMR spectroscopy
Eur. J. Biochem. 271, 4084-4093 (2004)              (mail for PDF reprint) and (supplementary material)

E. Liepinsh, M. Rakonjac, V. Boissoneault, P. Provost, B. Samuelsson, O. Rådmark, G. Otting
Letter to the Editor: NMR structure of human coactosin-like protein
J. Biomol. NMR 30, 353-356 (2004)                       (mail for PDF reprint)

G. Pintacuda, A. Moshref, A. Leonchiks, A. Sharipo, G. Otting
Site-specific labelling with a metal chelator for protein structure refinement
J. Biomol. NMR 29, 351-361 (2004)                       (mail for PDF reprint)

G. Pintacuda, M. A. Keniry, T. Huber, A. Y. Park, N. E. Dixon, G. Otting
Fast structure-based assignment of 15N-HSQC spectra of selectively 15N-labeled paramagnetic proteins
J. Am. Chem. Soc. 126, 2963-2970 (2004)           (mail for PDF reprint) and (supplementary material)

K. Modig, E. Liepinsh, G. Otting, B. Halle
Dynamics of protein and peptide hydration
J. Am. Chem. Soc. 126, 102-114 (2004)                (mail for PDF reprint) and (supplementary material)

K. Loscha, A. J. Oakley, B. Bancia, P. M. Schaeffer, P. Prosselkov, G. Otting, M. C. J. Wilce, N. E. Dixon
Expression, purification, crystallization and NMR studies of the helicase interaction domain of Escherichia coli DnaG primase
Prot. Expr. Purif. 33, 304-310 (2003)                    (mail for PDF reprint)

E. Liepinsh, R. Barbals, E. Dahl, A. Sharipo, E. Staub, G. Otting
Death-domain fold of ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition
J. Mol. Biol. 332, 1155-1163 (2003)                         (mail for PDF reprint)

S. Usami, K. Takahashi, I. Yuge, A. Ohtsuka, A. Namba, S. Abe, E. Fransen, L. Patthy, G. Otting, G. Van Camp
Mutations in the COCH gene are a frequent cause of autosomal dominant progressive cochleo-vestibular dysfunction, but not of Meniere's disease
Eur. J. Hum. Genet. 11, 744-748 (2003)                 (mail for PDF reprint)

G. Pintacuda, K. Hohenthanner, G. Otting, N. Müller
Angular dependence of dipole-dipole Curie spin cross-correlation effects in high-spin and low-spin paramagnetic myoglobin
J. Biomol. NMR 27, 115-132 (2003)                         (mail for PDF reprint)

E. Liepinsh, L. Banyai, G. Pintacuda, M. Trexler, L. Patthy, G. Otting
NMR structure of the netrin-like domain of human type I procollagen C-proteinase enhancer defines structural conservation of NTR domains and assesses potential proteinase inhibitory activity and ligand binding
J. Biol. Chem. 278, 25982-25989 (2003)                 (mail for PDF reprint)

E. Liepinsh, C. Genereux, D. Dehareng, B. Joris, G. Otting
NMR structure of Citrobacter freundii AmpD, comparison with T7 lysozyme and homology with PGRP domains
J. Mol. Biol. 327, 833-842 (2003)                                (mail for PDF reprint)

E. Liepinsh, A. Leonchiks, A. Sharipo, L. Guignard, G. Otting
Solution structure of the R3H domain from human Smbp-2
J. Mol. Biol. 326, 217-223 (2003)                                (mail for PDF reprint)

L. Guignard, K. Ozawa, S. E. Pursglove, G. Otting, N. E. Dixon
NMR analysis of in vitro-synthesized proteins without purification: a high-throughput approach
FEBS Lett. 524, 159-162 (2002)                                (mail for PDF reprint)

M. Bellanda, E. Peggion, G. Otting, J. Weigelt, E. Perdona, E. Domenici, C. Marchioro, S. Mammi
Backbone 1H, 13C and 15N resonance assignment of the N-terminal 24 kDa Fragment of the gyrase B subunit from E. coli
J. Biomol. NMR 22, 369-370 (2002)                          (mail for PDF reprint)

E. Liepinsh, G. Otting, M. M. Harding, L. G. Ward, J. P. Mackay, A. D. J. Haymet
Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein
Eur. J. Biochem. 269, 1259-1266 (2002)                    (mail for PDF reprint)

N. K. Williams, P. Prosselkov, E. Liepinsh, I. Line, A. Sharipo, D. R. Littler, P. M. G. Curmi, G. Otting, N. E. Dixon
In vivo protein cyclization promoted by a circularly-permuted Synechocystis sp. PCC6803 DnaB mini-intein
J. Biol. Chem. 277, 7790-7798 (2002)                         (mail for PDF reprint)

G. Pintacuda, G. Otting
Identification of protein surfaces by NMR measurements with a paramagnetic Gd(III) chelate
J. Am. Chem. Soc. 124, 372-373 (2002)                       (mail for PDF reprint and supplementary material)

E. Liepinsh, M. Trexler, A. Kaikkonen, J. Weigelt, L. Banyai, L. Patthy, G. Otting
NMR structure of the LCCL domain and implications for DFNA9 deafness disorder
EMBO J. 20, 5347-5353 (2001)                                   (mail for PDF reprint)

P. B. Crowley, G. Otting, B. G. Schlarb-Ridley, G. W. Canters, M. Ubbink
Hydrophobic interactions in a cyanobacterial plastocyanin-cytochrome f complex
J. Am. Chem. Soc. 123, 10444-10453 (2001)                (mail for PDF reprint and supplementary material)

E. Liepinsh, M. Baryshev, A. Sharipo, M. Ingelman-Sundberg, G. Otting, S. Mkrtchian
Thioredoxin-fold as a homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa homodimer
Structure 9, 457-471 (2001)                                          (mail for PDF reprint)

A. Kaikkonen, G. Otting
Residual dipolar 1H-1H couplings of methyl groups in weakly aligned proteins
J. Am. Chem. Soc. 123, 1770-1771 (2001)                (mail for PDF reprint and supplementary material)

A. Kaikkonen, G. Otting
Sensitive 1H-31P correlations with 5' methylene protons of DNA via homonuclear double-quantum coherence
J. Biomol. NMR 19, 273-277 (2001)                           (mail for PDF reprint)

J. A. Wilce, J. P. Vivian, A. F. Hastings, G. Otting, R. H. A. Folmer, I. G. Duggin, R. G. Wake, M. C. J. Wilce
Structure of the RTP-DNA complex and the mechanism of polar replication fork arrest
Nature Struct. Biol. 8, 206-210 (2001)                          (mail for PDF reprint)

Y. Yang, W. J. Griffiths, M. Nordling, J. Nygren, L. Möller, J. Bergman, E. Liepinsh, G. Otting, J.-A. Gustafsson, J. Rafter, J. Sjövall
Ring opening of benzo[a]pyrene in the germfree rat is a novel pathway for formation of potentially genotoxic metabolites
Biochemistry 39, 15585-15591 (2000)                        (mail for PDF reprint)

K. Nordstrand, A. Sandström, F. Aslund, A. Holmgren, G. Otting, K. D. Berndt
NMR structure of oxidized Glutaredoxin 3 from Escherichia coli
J. Mol. Biol. 303, 423-432 (2000)                                  (mail for PDF reprint)

M. Rückert, G. Otting
Alignment of biological macromolecules in novel nonionic liquid crystalline media for NMR experiments
J. Am. Chem. Soc. 122, 7793-7797 (2000)                 (mail for PDF reprint and supplementary material)

S. Hamdan, S. E. Brown, P. R. Thompson, J. Y. Yang, P. D. Carr, D. L. Ollis, G. Otting, N. E. Dixon
Preliminary X-ray crystallographic and NMR studies on the exonuclease domain of the epsilon subunit of E. coli DNA polymerase III
J. Struct. Biol. 131, 164-169 (2000)                               (mail for PDF reprint)

G. Otting, M. Rückert, M. H. Levitt, A. Moshref
NMR experiments for the sign determination of homonuclear scalar and residual dipolar couplings
J. Biomol. NMR 16, 343-346 (2000)                              (mail for PDF reprint)

P. Andersson, G. Otting
Time-shared X(w1)-half-filter for improved sensitivity in subspectral editing
J. Magn. Reson. 144, 168-170 (2000)                          (mail for PDF reprint)

P. Crowley, M. Ubbink, G. Otting
Phi angle restraints in protein backbones from dipole-dipole cross-correlation between 1HN-15N and 1HN-1Ha vectors
J. Am. Chem. Soc. 122, 2968-2969 (2000)                   (mail for PDF reprint and supplementary material)

R. Folmer, G. Otting
Sensitivity enhancement in (HCA)CONH experiments
J. Biomol. NMR 16, 229-233 (2000)                               (mail for PDF reprint)

M. Miteva, M. Andersson, A. Karshikoff, G. Otting
Molecular electroporation: a unifying concept for the description of membrane pore formation by antibacterial peptides, exemplified with NK-lysin
FEBS Lett. 462, 155-158 (1999)                                       (mail for PDF reprint)

E. Liepinsh, P. Sodano, S. Tassin, D. Marion, F. Vovelle, G. Otting
Solvation study of the non-specific lipid transfer protein from wheat by intermolecular NOEs with water and small organic molecules
J. Biomol. NMR 15, 213-225 (1999)                               (mail for PDF reprint) and supplementary material (without spectra)

K. Nordstrand, F. Aslund, S. Meunier, A. Holmgren, G. Otting, K. D. Berndt
Direct NMR observation of the Cys14 thiol proton of reduced Escherichia coli glutaredoxin-3 supports the presence of an active site thiol-thiolate hydrogen bond
FEBS Lett. 449, 196-200 (1999)                                       (mail for PDF reprint)

J. Weigelt, S. E. Brown, C. S. Miles, N. E. Dixon, G. Otting
NMR structure of the N-terminal domain of E. coli DnaB helicase: implications for structure rearrangements in the helicase hexamer
Structure 7, 681-690 (1999)                                               (mail for PDF reprint)

G. Otting, L. P. Soler, B. A. Messerle
Measurement of magnitude and sign of heteronuclear coupling constants in transition metal complexes
J. Magn. Reson. 137, 413-429 (1999)                            (mail for PDF reprint)

L. L. Ilag, C. Rottenberger, E. Liepinsh, G. Wellnhofer, F. Rudert, G. Otting, L. L. Ilag
Selection of a peptide ligand to the p75 neurotrophin receptor death domain and determination of its binding site by NMR
Biochem. Biophys. Res. Commun. 255, 104-109 (1999)          (mail for PDF reprint)

K. Nordstrand, F. Aslund, A. Holmgren, G. Otting, K. D. Berndt
NMR structure of Escherichia coli glutaredoxin 3 - glutathione mixed disulfide complex: implications for enzymatic mechanism
J. Mol. Biol. 286, 541-552 (1999)                                       (mail for PDF reprint)

A. Leonchiks, E. Liepinsh, M. Barishev, A. Sharipo, M. G. Masucci, G. Otting
Random coil conformation of a Gly/Ala-rich insert in IkBa excludes structural stabilization as the mechanism for protection against proteasomal degradation
FEBS Lett. 440, 365-369 (1998)                                       (mail for PDF reprint)

E. Liepinsh, G. Otting
Water-protein NOEs: optimized scheme for selective water excitation
J. Biomol. NMR 13, 73-76 (1999)                                    (Abstract)

J. Weigelt
Single scan, sensitivity and gradient enhanced TROSY for multidimensional NMR experiments
J. Am. Chem. Soc. 120, 10778-10779 (1998)                 (mail for PDF reprint and errata)

M. Sunnerhagen, V. P. Denisov, K. Venu, A. M. J. J. Bonvin, J. Carey, B. Halle, G. Otting
Water molecules in DNA recognition I: hydration lifetimes of the trp operator in solution measured by NMR spectroscopy
J. Mol. Biol. 282, 847-858 (1998)                                       (mail for PDF reprint)

A. M. J. J. Bonvin, M. Sunnerhagen, G. Otting, W. F. van Gunsteren
Water molecules in DNA recognition II: a molecular dynamics view of the structure and hydration of the trp operator
J. Mol. Biol. 282, 859-873 (1998)                                       (mail for PDF reprint)

P. Andersson, A. Annila, G. Otting
An a/b-HSQC-a/b experiment for spin-state selective editing of IS cross peaks
J. Magn. Reson. 133, 364-367 (1998)                              (mail for PDF reprint)

P. Andersson, J. Weigelt, G. Otting
Spin-state selection filters for the measurement of heteronuclear one-bond coupling constants
J. Biomol. NMR 12, 435-441 (1998)                                  (Abstract)

H. Ponstingl, G. Otting
Rapid measurement of scalar three-bond ¹H^N-¹H^a spin coupling constants in ¹⁵N-labelled proteins
J. Biomol. NMR 12, 319-324 (1998)                                  (Abstract)

J.-M. Ruysschaert, E. Goormaghtigh, F. Homble, M. Andersson, E. Liepinsh, G. Otting
Lipid membrane binding of NK-lysin
FEBS Lett. 425, 341-344 (1998)                                          (mail for PDF reprint)

P. Andersson, K. Nordstrand, M. Sunnerhagen, E. Liepinsh, I. Turovskis, G. Otting
Heteronuclear correlation experiments for the determination of one-bond coupling constants
J. Biomol. NMR 11, 445-450 (1998)                                   (Abstract)

E. Liepinsh, M. Kitamura, T. Murakami, T. Nakaya, G. Otting
Common ancestor of serine proteases and flavin-binding domains
Nature Struct. Biol. 5, 102-103 (1998)                                (Abstract)

J. Weigelt, C. S. Miles, N. E. Dixon, G. Otting
Backbone NMR assignments and secondary structure of the N-terminal domain of DnaB helicase from E. coli
J. Biomol. NMR 11, 233-234 (1998)                                   (Abstract)

M. Hamberg, E. Liepinsh, G. Otting, W. Griffiths
Isolation and structure of an unusual galactolipid from oat seeds
Lipids 33, 355-363 (1998)                                                    (Abstract)

E. Liepinsh, M. Kitamura, T. Murakami, T. Nakaya, G. Otting
Pathway of chymotrypsin evolution suggested by the structure of the FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F)
Nature Struct. Biol. 4, 975-978 (1997)                               (mail for PDF)

P. Andersson, B. Gsell, B. Wipf, H. Senn, G. Otting
HMQC and HSQC experiments with water flip-back optimized for large proteins
J. Biomol. NMR 11, 279-288 (1998)                                  (Abstract)

G. Otting
NMR studies of water bound to biological molecules
Prog. NMR Spectr. 31, 259-285 (1997)                            (mail for PDF reprint)

M. Sunnerhagen, M. Nilges, G. Otting, J. Carey
Solution structure of the DNA-binding domain and model for the binding of multifunctional arginine repressor to DNA
Nature Struct. Biol. 4, 819-826 (1997)                               (Abstract)

H. Ponstingl, G. Otting
Detection of protein-ligand NOEs with small, weakly binding ligands by combined relaxation and diffusion filtering
J. Biomol. NMR 9, 441-444 (1997)                                    (Abstract)

E. Liepinsh, M. Andersson, J. Ruysschaert, G. Otting
Saposin fold revealed by the NMR structure of NK-lysin
Nature Struct. Biol. 4, 793-795 (1997)                               (Abstract)

E. Liepinsh, L. L. Ilag, G. Otting, C. Ibáñez
NMR structure of the death domain of the p75 neurotrophin receptor
EMBO J. 16, 4999-5005 (1997)                                          (mail for PDF reprint)

G. Otting, E. Liepinsh, B. Halle, U. Frey
Hydrophobic cavities with low water occupancies in protein structures: NMR identification by the use of small gas molecules
Nature Struct. Biol. 4, 396-404 (1997)                               (Abstract)

C. S. Miles, J. Weigelt, N. P. S. Stamford, N. Dammerova, G. Otting, N. E. Dixon
Precise limits of the N-terminal domain of DnaB helicase determined by NMR spectroscopy
Biochem. Biophys. Res. Commun. 231, 126-130 (1997)          (mail for PDF reprint)

E. Liepinsh, G. Otting
Organic solvents identify specific ligand binding sites on protein surfaces
Nature Biotech. 15, 264-268 (1997)                                   (Abstract)

G. Otting, B. A. Messerle, L. P. Soler
1H detected multinuclear NMR experiments for the measurement of small heteronuclear coupling constants in transition metal complexes
J. Am. Chem. Soc. 119, 5425-5434 (1997)                       (mail for PDF reprint)

G. Otting
A DQ/ZQ NMR experiment for the determination of the signs of small J(¹H,¹³C) coupling constants in linear spin systems
J. Magn. Reson. 124, 503-505 (1997)                               (mail for PDF reprint)

G. Otting, B. A. Messerle, L. P. Soler
¹H-detected, gradient-enhanced ¹⁵N and ¹³C NMR experiments for the measurement of small heteronuclear coupling constants and isotopic shifts
J. Am. Chem. Soc. 118, 5096-5102 (1996)                       (mail for PDF reprint)

H. Ponstingl, G. Otting
NMR assignments, secondary structure and hydration of E. coli flavodoxin
Eur. J. Biochem. 244, 384-399 (1997)                               (Abstract)

A. Hammarström, K. D. Berndt, R. Sillard, K. Adermann, G. Otting
Solution structure of a naturally-occuring zinc-peptide complex demonstrates that the N-terminal zinc-binding module of the Lasp-1 LIM domain is an independent folding unit
Biochemistry 35, 12723-12732 (1996)                             (mail for PDF reprint)

E. Liepinsh, G. Otting
Proton exchange rates from amino acid sidechains - implications for image contrast
Magn. Reson. Med. 35, 30-42 (1996)                                 (mail for P DF reprint)

A. Jacobson, W. Leupin, E. Liepinsh, G. Otting
Minor groove hydration of DNA in aqueous solution, sequence dependent next-neighbor effect on the hydration lifetimes in d-(TTAA)₂ segments measured by NMR spectroscopy
Nucl. Acids Res. 24, 2911-2918 (1996)

F. Åslund, K. Nordstrand, K. D. Berndt, M. Nikkola, T. Bergman, H. Ponstingl, H. Jörnvall, G. Otting, A. Holmgren
Glutaredoxin-3 from Escherichia Coli: amino acid sequence, ¹H and ¹⁵N NMR assignments and structural analysis
J. Biol. Chem. 271, 6736-6745 (1996)

J. Weigelt, A. Hammarström, W. Bermel, G. Otting
Removal of zero-quantum coherence in protein spectra using SESAM decoupling and suppression of decoupling sidebands
J. Magn. Reson. B 110, 219-224 (1996)

K. Nordstrand, H. Ponstingl, A. Holmgren, G. Otting
Resonance assignment and structural analysis of acid denatured E. coli [U-¹⁵N]- glutaredoxin 3. Use of 3D ¹⁵N-HSQC-(TOCSY-NOESY)-¹⁵N-HSQC
Eur. Biophys. J. 24, 179-184 (1996)

S. Mattila, A. M. P. Koskinen, G. Otting
Long-range HSQC with spin-lock purge pulses for the observation of
heteronuclear correlations with ¹H detection and low t₁-noise
J. Magn. Reson. B 109, 326-328 (1995)

J. Weigelt, G. Otting
¹³C-Relayed ¹³C HSQC at natural isotopic abundance
J. Magn. Reson. A 116, 133-134 (1995)

R. Eliasson, P. Reichard, E. Mulliez, S. Ollagnier, M. Fontecave, E. Liepinsh, G. Otting
The mechanism of the anaerobic Escherichia coli ribonucleotide reductase
investigated with nuclear magnetic resonance spectrocopy
Biochem. Biophys. Res. Commun. 214, 28-35 (1995)

E. Liepinsh, G. Otting
Selective excitation of intense solvent signals in the presence of radiation damping
J. Biomol. NMR 5, 420-426 (1995)

G. Otting, E. Liepinsh
Selective excitation of the water signal by a Q-switched selective pulse
J. Magn. Reson. B 107, 192-196 (1995)

A. Hammarström, G. Otting
Enhanced spectral resolution and sensitivity in the COSY fingerprint region of
polypeptides
J. Magn. Reson. B 108, 86-88 (1995)

J. Weigelt, G. Otting
¹H detected INEPT-INADEQUATE at natural ¹³C abundance
J. Magn. Reson. A 113, 128-130 (1995)

C. Anklin, M. Rindlisbacher, G. Otting, F. H. Laukien
A probehead with switchable quality factor. Suppression of radiation damping
J. Magn. Reson. B 106, 199-201 (1995)

G. Otting, E. Liepinsh
Protein hydration by high-resolution NMR spectroscopy - Implications for MR
image contrast
Acc. Chem. Res. 28, 171-177 (1995)

A. Hammarström, G. Otting
Improved spectral resolution in ¹H NMR spectroscopy by homonuclear semi-
selective shaped pulse decoupling during acquisition
J. Am. Chem. Soc. 116, 8847-8848 (1994)

E. Liepinsh, G. Otting
Specificity of urea binding to proteins
J. Am. Chem. Soc. 116, 9670-9674 (1994)

E. Liepinsh, W. Leupin, G. Otting
Hydration of DNA in aqueous solution: NMR evidence for a kinetic
destabilization of the minor groove hydration of d-(TTAA)2 versus d-(AATT)2 segments
Nucl. Acid Res. 22, 2249-2254 (1994)

G. Otting
¹H-¹³C half-filter experiments
Encyclopedia of Nuclear Magnetic Resonance, Vol. 4, pp. 2242-2245, D. M. Grant, R. K. Harris Eds., J.
Wiley & Sons, Chichester (1996)

G. Otting
Protein hydration
Encyclopedia of Nuclear Magnetic Resonance, Vol. 6, pp. 3796-3800, D. M. Grant, R. K. Harris Eds.,
J. Wiley & Sons, Chichester (1996)

W. J. Gehring, Y. Q. Qian, M. Billeter, K. Furukubo-Tokunaga, A. F. Schier, D. Resendez-Perez, M. Affolter, G. Otting, K. Wüthrich
Homeodomain - DNA recognition
Cell 78, 211-223 (1994)

E. Liepinsh, K. D. Berndt, R. Sillard, V. Mutt, G. Otting
Solution structure and dynamics of PEC-60, a protein of the Kazal-type inhibitor family, determined by nuclear magnetic resonance
J. Mol. Biol. 239, 137-153 (1994)

A. Hammarström, G. Otting
Axial peak artifacts in multi-pulse NMR experiments
J. Magn. Reson. A 109, 246-249 (1994)

Otting, M. Billeter, K. Wüthrich, H. Roth, C. Leumann, A. Eschenmoser
Warum Pentose- und nicht Hexose-Nucleinsauren? Teil IV 'Homo-DNS': ¹H-, ¹³C-, ³¹P- und ¹⁵N-NMR-spektroskopische Untersuchung von ddGlc(A-A-A-A-A-T-T-T-T-T) in wassriger Lösung
Helv. Chim. Acta 76, 2701-2756 (1993)

G. Otting
Improved resolution and sensitivity in NOE and ROE experiments with water by the use of B₁-gradients
J. Magn. Reson. B 103, 288-291 (1994)

Contact us:

by e-mail
     Gottfried.Otting@anu.edu.au
by phone
     +61-2-6125 6507
by fax
     +61-2-6125 0750
postal address
     Australian National University
     Research School of Chemistry
     Canberra, ACT 0200
     Australia

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