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Other Collaborative Research
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- Synthesis of compounds for biomolecular NMR studies
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When proteins are tagged by fluorinated amino acids, proteins can be analysed using 19F NMR spectroscopy.
This is a particularly useful addition to the solution phase analysis of the proteins thanks to its simple spin system.
For this reason, we have developed a simple method to incorporate fluorine to an aliphatic amino acid, leucine.
Using our method, leucine was regio- and stereoselectively fluorinated to give (S)-γ-fluoroleucine.
Now we are exploring the incorporation of this aliphatic fluorinated amino acid into proteins by cell-free protein synthesis with Otting group.
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Ms. Dharshana Padmakshan
(PhD Students, 2004-)
Research Interest: Synthesis of compounds for biomolecular NMR studies
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Stereocontrolled synthesis of (S)-γ-fluoroleucine
Padmakshan, D., Bennett, S. A., Otting, G., Easton, C. J., Synlett, 7 (2007), 1083-1084.
DOI:10.1055/s-2007-977420
Aromatic chlorination of ω-phenylalkylamines and ω-phenylalkylamides in carbon tetrachloride and α,α,α-trifluorotoluene
O'Connell, J. L., Simpson, J. S., Dumanski, P. G., Simpson, G. W. and Easton, C. J., Org. Biomol. Chem., 4 (2006), 2716-2723.
DOI:10.1039/b605010g
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Activators and inhibitors of ryanodine receptor calcium ion channels
With J K Robinson, and A Dulhunty, M Casarotto [JCSMR, ANU], M Miller [Biotron Ltd, Canberra]
Cycloaddition reactions of nitrile oxides
With G P Savage, G W Simpson [CSIRO Molecular Health and Technologies, Melbourne]
Lipid chemistry
With A Ferrante [Adelaide Medical Centre for Women and Children, SA]
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