McLeod, Dr Malcolm D. BSc (Hons) Monash PhD
Cambridge - Organic Synthesis and Catalysis
Bodkin JA, Bacskay GB, McLeod MD The Sharpless asymmetric
aminohydroxylation reaction: optimizing ligand/substrate control of
regioselectivity for the synthesis of 3- and 4-aminosugars. Org.
Biomol. Chem. (2008), 6(14), 2544-2553.http://dx.doi.org/10.1039/b803310b
McRobb L, Handelsman DJ, Kazlauskas R, Wilkinson S, McLeod
MD, Heather AK Structure-activity relationships of synthetic progestins
in a yeast-based in vitro androgen bioassay. J. Steroid
Biochem. Mol. Biol. (2008), 110(1-2), 39-47. http://dx.doi.org/10.1016/j.jsbmb.2007.10.008
Wilkinson SM, Liew CW, Mackay JP, Salleh HM, Withers SG,
McLeod, MD Escherichia coli glucuronylsynthase: an engineered
enzyme for the synthesis of β-glucuronides. Org. Lett.
(2008), 10(8), 1585-1588. http://dx.doi.org/10.1021/ol8002767
McKinneyA, Pu F, McLeod MD, Suann CJ, Stenhouse AM
17β-Hydroxy-3-oxoandrost-4-en-19-oic acid as a source of nandrolone in
acid solvolysed stallion urine extracts. In Proceedings of the 16th
International Conference of Racing Analysts and Veterinarians.
Houghton E, Kijima-Suda I, Wada R, Wade JF, eds. R&W Publications,
Newmarket, UK (2007) pp. 84-89.
Shuter EC, Duong H, Hutton CA, McLeod MD The
enantioselective synthesis of APTO and AETD: polyhydroxylated β-amino acid
constituents of the microsclerodermin cyclic peptides. Org. Biomol.
Chem. (2007), 5(19), 3183-3189. http://dx.doi.org/10.1039/b707891a
Amoroso S, Agon VV, Starke-Peterkovic T, McLeod MD, Apell
H-J, Sebban P, Clarke RJ Photochemical behavior and
Na+,K+-ATPase sensitivity of voltage-sensitive
styrylpyridinium fluorescent membrane probes. Photochem.
Photobiol. (2006), 82(2), 495-502. http://dx.doi.org/10.1562/2005-06-08-RA-569
Halliday JI, Chebib M, Turner P, McLeod MD Double-Mannich
annulation of cyclic ketones using N,N-bis(ethoxymethyl)alkylamine
reagents. Org. Lett. (2006), 8(15), 3399-3401. http://dx.doi.org/10.1021/ol061242s
Hungerford NL, McKinney AR,
Stenhouse AM, McLeod MD Selective manipulation of
steroid hydroxyl groups with boronate esters: efficient access to
antigenic C-3 linked steroid-protein conjugates and steroid sulfate
standards for drug detection. Org. Biomol. Chem. (2006), 4(21),
3951-3959. http://dx.doi.org/10.1039/b610499a
Issa F, Kassiou M, Chan H-K, McLeod MD Synthesis and
radiolabelling of ipratropium and tiotropium for use as PET ligands in the
study of inhaled drug deposition. Aust. J. Chem. (2006), 59(1),
53-58. http://dx.doi.org/10.1071/CH05303
Louis I, Hungerford NL, Humphries EJ, McLeod MD
Enantioselective total synthesis of (–) dactylolide. Org.
Lett. (2006), 8(6), 1117-1120. http://dx.doi.org/10.1021/ol053092b
Barker D, Lin DH-S, Carland JE, Chu CP-Y, Chebib M, Brimble
MA, Savage GP, McLeod MD Methyllycaconitine analogues have mixed
antagonist effects at nicotinic acetylcholine receptors. Bioorg.
Med. Chem. (2005), 13(14), 4565-4575. http://dx.doi.org/10.1016/j.bmc.2005.04.054
Harding M, Bodkin JA, Hutton CA, McLeod MD Substrate
control in the asymmetric aminohydroxylation of monosubstituted alkenes:
the enantioselective synthesis of GABOB and homoserine derivatives.
Synlett (2005), (18), 2829-2831. http://dx.doi.org/10.1055/s-2005-918939
Hungerford NL, Sortais B, Smart CG, McKinney AR, Ridley DD,
Stenhouse AM, Suann CJ, Munn KJ, Sillence MN, McLeod MD Analysis of
anabolic steroids in the horse: development of a generic ELISA for the
screening of 17α-alkyl anabolic steroid metabolites. J.
Steroid Biochem. Mol. Biol. (2005), 96(3-4), 317-334. http://dx.doi.org/10.1016/j.jsbmb.2005.03.007
Hunter L, McLeod MD, Hutton CA Synthesis of the
β-hydroxydopa-γ-hydroxy-δ-sulfinylnorvaline component
of ustiloxins A and B. Org. Biomol. Chem. (2005), 3(5),
732-734. http://dx.doi.org/10.1039/b418876d
Banwell MG, Edwards AJ, McLeod MD, Stewart SG A
chemoenzymatic synthesis of the cis-decalin core associated with
the novel anti-mitotic agent phomopsidin: some observations concerning a
high-pressure-promoted Diels-Alder cycloaddition reaction of
(1S,2R)-3-methyl-cis-1,2-dihydrocatechol and the
anionic oxy-Cope rearrangement of compounds derived from the adduct.
Aust. J. Chem. (2004), 57(7), 641-644. http://dx.doi.org/10.1071/CH04036
Banwell MG, McLeod MD, Riches AG Taxane diterpene
synthesis studies. Part 2: towards taxinine-enantiospecific construction
of an AB-ring substructure incorporating both quaternary carbon centres
and attempts to annulate the C-ring. Aust. J. Chem. (2004),
57(1), 53-66. http://dx.doi.org/10.1071/CH03161
Barker D, Brimble MA, McLeod MD Synthesis of simple
analogues of methyllycaconitine - an efficient method for the preparation
of the N-substituted anthranilate pharmacophore.
Tetrahedron (2004), 60(28), 5953-5963. http://dx.doi.org/10.1016/j.tet.2004.05.024
Barker D, Brimble MA, McLeod MD, Savage GP Synthesis of
tricyclic analogues of methyllycaconitine using ring closing metathesis to
append a B ring to an AE azabicyclic fragment. Org. Biomol.
Chem. (2004), 2(11), 1659-1669. http://dx.doi.org/10.1039/b401119h
Brocke C, Brimble MA, Lin DS-H, McLeod MD Application of
a double Mannich reaction using bis(aminol) ethers in the synthesis of AE
ring analogues of methyl lycaconitine. Synlett (2004), (13),
2359-2363. http://dx.doi.org/10.1055/s-2004-831340
Pu F, McKinney AR, Stenhouse AM, Suann CJ, McLeod MD
Direct detection of boldenone sulfate and glucuronide conjugates in
horse urine by ion trap liquid chromatography-mass spectrometry. J.
Chromatogr. B (2004), 813(1-2), 241-246. http://dx.doi.org/10.1016/j.jchromb.2004.09.052
Banwell MG, Edwards AJ, Harfoot GJ, Jolliffe KA, McLeod MD,
McRae KJ, Stewart SG, Vögtle M Chemoenzymatic methods for the
enantioselective preparation of sesquiterpenoid natural products from
aromatic precursors. Pure Appl. Chem. (2003), 75(2-3), 223-229.
http://dx.doi.org/10.1351/pac200375020223
Banwell MG, Hockless DCR, McLeod MD Chemoenzymatic total
syntheses of the sesquiterpene (–)-patchoulenone. New J.
Chem. (2003), 27(1), 50-59. http://dx.doi.org/10.1039/b206372g
Barker D, Brimble MA, McLeod MD A convenient synthesis of
2-(3-methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid. Synthesis
(2003), (5), 656-658. http://dx.doi.org/10.1055/s-2003-38065
Bodkin JA, Humphries EJ, McLeod MD The total synthesis of
(-)-tetrahydrolipstatin. Tetrahedron Lett. (2003), 44(14),
2869-2872. http://dx.doi.org/10.1016/S0040-4039(03)00443-X
Bodkin JA, Humphries EJ, McLeod MD The total synthesis of
(-)-tetrahydrolipstatin. Aust. J. Chem. (2003), 56(8), 795-803.
http://dx.doi.org/10.1071/CH03121
Brimble MA, Davey RM, McLeod MD, Murphy M
C-Glycosylation of oxygenated naphthols with
3-dimethylamino-2,3,6-trideoxy-L-arabino-hexopyranose and
3-azido-2,3,6-trideoxy-D-arabino-hexopyranose. Aust. J. Chem.
(2003), 56(8), 787-794. http://dx.doi.org/10.1071/CH02236
Brimble MA, Davey RM, McLeod MD, Murphy M Synthesis of
3-azido-2,3,6-trideoxy-β-D-arabino-hexopyranosyl
pyranonaphthoquinone analogues of medermycin. Org. Biomol.
Chem. (2003), 1(10), 1690-1700. http://dx.doi.org/10.1039/b301449p
Barker D, Brimble MA, McLeod M, Savage GP, Wong DJ
Synthesis of ABE tricyclic analogues of methyllycaconitine using a
Wacker oxidation-aldol strategy to append the B ring to the AE
fragment. J. Chem. Soc., Perkin Trans. 1 (2002), (7), 924-931.
http://dx.doi.org/10.1039/b200073n
Barker D, McLeod MD, Brimble MA, Savage GP Application of
olefin metathesis to the synthesis of ABE ring analogues of
methyllycaconitine. Tetrahedron Lett. (2002), 43(34),
6019-6022. http://dx.doi.org/10.1016/S0040-4039(02)01214-5
Bodkin JA, McLeod MD The Sharpless asymmetric
aminohydroxylation. J. Chem. Soc., Perkin Trans. 1 (2002),
(24), 2733-2746. http://dx.doi.org/10.1039/b111276g
Brimble MA, Davey RM, McLeod MD Synthesis of azido
analogues of medermycin. Synlett (2002), (8), 1318-1322.
http://dx.doi.org/10.1055/s-2002-32955
Barker D, McLeod MD, Brimble MA, Savage GP A high
yielding synthesis of anthranilate esters from sterically hindered
alcohols. Tetrahedron Lett. (2001), 42(9), 1785-1788.
http://dx.doi.org/10.1016/S0040-4039(00)02327-3
Paterson I, Doughty VA, Florence G, Gerlach K, McLeod MD,
Scott JP, Trieselmann T Asymmetric aldol reactions using boron
enolates: applications to polyketide synthesis. In Organoboranes
for Syntheses, Ramachandran PV, Brown HC, Eds. ACS Symposium Series
783, American Chemical Society: Washington, DC (2001), pp. 195-206.
Banwell MG, McLeod MD, Premraj R, Simpson GW Improved
synthetic route to enantiomerically pure samples of the
tetrahydropyran-2-ylacetic acid core associated with the phytotoxic
polyketide herboxidiene. Aust. J. Chem. (2000), 53(8), 659-664.
http://dx.doi.org/10.1071/CH00083
Banwell M, McLeod M, Premraj R, Simpson G Total synthesis
of herboxidiene, a complex polyketide from Streptomyces species
A7847. Pure Appl. Chem. (2000), 72(9), 1631-1634. http://dx.doi.org/10.1351/pac200072091631
Davey RM, Brimble MA, McLeod MD Regioselective asymmetric
aminohydroxylation of precursors to 2,3,6-trideoxy-3-aminohexoses.
Tetrahedron Lett. (2000), 41(26), 5141-5145. http://dx.doi.org/10.1016/S0040-4039(00)00798-X
Paterson I, Doughty VA, McLeod MD, Trieselmann T Total
synthesis of (+)-concanamycin F. Angew. Chem., Int. Ed. (2000),
39(7), 1308-1312.
http://dx.doi.org/10.1002/(SICI)1521-3773(20000403)39:7<1308::AID-ANIE1308>3.0.CO;2-7
Banwell MG, Darmos P, McLeod MD, Hockless DCR From
toluene to TaxolTM: chemoenzymatic and
enantiodivergent routes to the AB-ring systems of taxoids and
ent-taxoids.
Synlett (1998), (8), 897-899. http://dx.doi.org/10.1055/s-1998-1801
Banwell M, McLeod M Chemoenzymatic total synthesis of the
sesquiterpene (–) patchoulenone. Chem. Commun. (1998),
(17), 1851-1852. http://dx.doi.org/10.1039/a804980g
Paterson I, McLeod MD Studies in macrolide synthesis:
stereocontrolled synthesis of a C1-C13 segment of
concanamycin A. Tetrahedron Lett. (1997), 38(23), 4183-4186.
http://dx.doi.org/10.1016/S0040-4039(97)00816-2
Bourke DG, Collins DJ, Hibberd AI, McLeod MD Enolic ortho
esters. VI. A new 'pyranose → cyclohexane' transformation via
1,6-dideoxy-1,1-ethylenedioxy-2,3,4-tri-O-methyl-D-xylo-hex-5-enopyranose.
Aust. J. Chem. (1996), 49(3), 425-434. http://dx.doi.org/10.1071/CH9960425
Paterson I, Bower S, McLeod MD Stereocontrolled aldol
additions to α-methylene-β-alkoxy aldehydes: application to
the synthesis of a C13-C25 segment of bafilomycin
A1. Tetrahedron Lett. (1995), 36(1), 175-178.
http://dx.doi.org/10.1016/0040-4039(94)02205-P
Paterson I, McLeod MD Studies in macrolide synthesis: a sequential aldol/glycosylation approach to the synthesis of concanamycin A. Tetrahedron Lett. (1995), 36(49), 9065-9068. http://dx.doi.org/10.1016/0040-4039(95)01913-3